watch 01:11 The Loop (TV) Do you like this video? A cuticle is any layer of cells that creates and protects keratin. In humans, it appears at the base of hair shafts, fingernails and toenails. Discolored or abnormally shaped cuticles can indicate several conditions. Cuticle at Wikipedia Retrieved from "https://house.fandom.com/wiki/Cuticle?oldid=45526" Categories: Anatomy Add category Cancel Save Community content is available under CC-BY-SA unless otherwise noted.