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Diane is one of the patients in Ward 6 at Mayfield Psychiatric Hospital in the episode Broken. She is the patient with the blonde, curly hair who wears thick glasses. She is portrayed by actress Artemis Pebdani.

Diane's illness is never disclosed or described, but her doctors have recommended electroconvulsive therapy and she expresses that she is worried about it.

House meets Diane while he is playing Blind Man's Bluff with the other patients. He uses the reflection in her glasses to cheat and see his own card and folds.

Diane performs The Macarena with Dr. Beasley at the talent show.