Gregory House is often seen playing with his GameBoy Advance and later Nintendo DS in early seasons of House. Often times he is shown playing Metroid Prime Hunters, albeit with sound more fitting of a 1980's style game. In Distractions, he hands his GameBoy to a clinic patient while he talks to Wilson. In Lines in the Sand, an autistic child gives House his PSP (Playstation Portable) as a gift for treating him, and after this we do not see House's GBA or NDS. House has also been shown to play XBOX 360 in the season 5 pilot, Dying Changes Everything.

"What are you doing?" "Level four." ~ Gregory House when asked by a clinic patient about his gaming.

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