House's Motorcycle is the motorcycle used by House to get from place to place. It is a Honda CBR1000RR Fireblade in Repsol finish.
The CBR1000RR is a 999 cc (61.0 cu in) liquid-cooled inline four-cylinder sport bike that was introduced by Honda in 2004 to replace the CBR954RR.
The 2004 Fireblade developed 172 horsepower from a 998cc engine, more than House's car.
House test rode an Aprilia RSV1000R at the end of the Season 2 episode Autopsy. The RSV and the CBR are similar motorcycles in their racing-oriented appearance, however the RSV1000R produces power from a 60 degree, liquid-cooled, 1000cc V-twin engine.
House purchased the 2005 CBR1000RR Fireblade with borrowed money from Wilson even though he had enough money to buy it himself because he wanted to see how much Wilson would lend him (in this case, $5,000). He paid Wilson back in Daddy's Boy in an attempt to get him to disinvite House's parents from dinner, but Wilson took the money and invited House's parents to dinner anyway.
In Daddy's Boy, House mentions that he purchased the motorcycle from an architect that "couldn't separate braking and turning". As a result of this, the motorcycle has a considerable amount of damage on the right side (akin to House's right leg) from an accident, and House was able to purchase the motorcycle at a discounted rate.