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About House, M.D.

House, also known as House, M.D., was a critically-acclaimed American medical drama television series created by David Shore and executively produced by film director Bryan Singer. The Emmy and Peabody award-winning medical drama debuted on the FOX Network on November 16, 2004, and aired its last episode on May 21, 2012.

For eight years the show brought in people from around the globe, bringing intrigue and mystery in the form of unusual medical cases in a vein reminiscent of the mysteries solved by Sherlock Holmes. Furthermore, these cases were the catalyst for the discussion of philosophical and ethical issues and decisions, a lot of which were not left with a clear victor, but all of which revealed more and more of the character of each of the different doctors that comprised the team each year. In the end, while the team didn't completely understand (or appreciate) House's methods fully, the show gives a final hurrah as each of the members walks away with something they realize was the right thing to do after all. Although the mantra "Everybody Lies" is proven over and over again, the concept that "people never change, they only come up with better lies" is tested up until the last moments as the characters (and the show) drive off into an adventure left to the imagination.

Everything is challenged, nothing is sacred, and the most profound revelations of life can be found within the 172 hours of television given over the course of the eight seasons of pill-popping, dripping sarcasm, dark humor, and intelligent storytelling ever to grace the small screen of the living room (or large screen, if that may be the case, but then...everybody lies). This wiki is intended for your perusal to catch up, read, make new or more complete connections on the various subject matter, or perhaps relive the funny if outrageous times given to us by actor Hugh Laurie and company.

Enjoy!

Current Featured Article

Amyloid fibril formation and classic facial features of AL amyloidosis.jpg
Amyloidosis


Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue There are several types with varying symptoms; signs and symptoms may include diarrhea, weight loss, feeling tired, enlargement of the tongue, bleeding, numbness, feeling faint with standing, swelling of the legs, or enlargement of the spleen.

There are about 30 different types of amyloidosis, each due to a specific protein misfolding. Some are genetic while others are acquired. They are grouped into localized forms, and systemic ones. The four most common types of systemic amyloidosis are light chain (AL), inflammation (AA), dialysis-related (Aβ2M), and hereditary and old age (ATTR and familial amyloid polyneuropathy.

Diagnosis may be suspected when protein is found in the urine, organ enlargement is present, or problems are found with multiple peripheral nerves and it is unclear to the physician why this might be so. Diagnosis is confirmed by tissue biopsy. Due to the variable presentation, a diagnosis can often take some time to reach.

Treatment is geared towards decreasing the amount of the involved protein. This may sometimes be achieved by determining and treating the underlying cause. AL amyloidosis occurs in about 3–13 per million people per year and AA amyloidosis in about 2 per million people per year. The usual age of onset of these two types is 55 to 60 years old. Without treatment, life expectancy is between six months and four years. In the developed world about 1 per 1,000 people die annually from amyloidosis. Amyloidosis has been described since at least 1639.

Signs and symptoms

The presentation of amyloidosis is broad and depends on the site of amyloid accumulation. The kidney and heart are the most common organs involved.

Kidneys

Amyloid deposition in the kidneys can cause nephrotic syndrome, which results from a reduction in the kidney's ability to filter and hold on to proteins. The nephrotic syndrome occurs with or without elevations in creatinine and blood urea concentration, two biochemical markers of kidney injury. In AA amyloidosis, the kidneys are involved in 91–96% of people, symptoms ranging from protein in the urine to nephrotic syndrome and rarely chronic kidney disease.


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Current Featured Quote

House: "Is this hell? An eternity of people trying to convince me to live?"
Cameron: "Who says I'm here to convince you to live?"
―Cameron's hallucination appears in Everybody Dies
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House Wiki Bulletin Board

We are devastated to announce the death of Skye McCole Bartusiak (Kids), apparently from the complications of epilepsy at the age of 21.

Another big milestone! Our 5,000th article! True, it's a stub, buy you can all help with that!

The lovely Amanda Leighton is our 1,000th picture file!

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SteveHFisyh SteveHFisyh 8 days ago
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October 2021 featured article

The featured article for next month will be Walter Cofield. Please help us improve it to featured article quality

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SteveHFisyh SteveHFisyh 12 August
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September 2021 Featured Article

Next month's featured article will be one of our favourite diseases - Amyloidosis

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SteveHFisyh SteveHFisyh 1 July
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August 2021 Featured Article

Next month's featured article will be a patient - Sister Mary Augustine. Please help us improve it to featured article quality.

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SteveHFisyh SteveHFisyh 12 June
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July 2021 Featured Article

On behalf of Eric Foreman, it's time to beef up the article on Neurology. Help us improve it to featured article level

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