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"He paid for your lunch, liked monster trucks, and was your conscience."
―Kutner reminding House what Wilson did for him in Not Cancer

James Evan Wilson was a major character on House from the first season until the end of the series. He was the Head of Oncology at Princeton-Plainsboro Teaching Hospital and also Dr. Gregory House's sole good friend up until his resignation from the hospital and (probable, due to his refusal to continue treatment) eventual death from Thymoma, which he was officially diagnosed with in the Season 8 episode, Body and Soul. Wilson acts as House’s conscience, sounding board, and the enabler of his abusive personality.

He has been married and divorced three times (his first wife was Sam Carr, the second wife was Bonnie Wilson, the third Julie Wilson). He has had a relationship with one of his terminally ill patients, and dated one of House's rejected applicants, Amber Volakis until her untimely death. Wilson states in Season 1 that he has no children. He does seem to suggest to last girlfriend Sam (also his first wife) that he wants a child with her in Season 7, as when she says she should get a puppy, he replies, "Or pregnant." He proposed to her in the following episode, but it resulted in her leaving him.

He has been treated for clinical depression. Although he cares deeply for House, he often goes behind his back in attempts to help him. For example, although Cuddy proposed the bet to House that he give up Vicodin for a week in order to reduce his clinic duty, it was Wilson's idea. It was also Wilson's idea not to tell House that he was right about Richard McNeil suffering from Addison's disease.

Wilson has gone to extreme lengths to protect and support House, as well as enable House's abusive and manipulative behavior:

  • He was the only board member to vote against firing House in order to satisfy Edward Vogler, which cost him his spot on the board and almost cost him his job.
  • He lied to Michael Tritter when House forged Wilson's signature on Wilson's prescription pad. After Wilson admitted the forgery to Tritter, he once again refused to cooperate with Tritter after House saved yet another patient no-one else could.
  • He was always by House's side when Stacy Warner left him, which eventually cost Wilson his second wife.

He was portrayed by American actor Robert Sean Leonard.

Character Biography

Wilson is one of three brothers. He has an undergraduate degree from McGill University, and graduate degrees from Columbia University and the University of Pennsylvania. His father is Christian and his mother is Jewish; he was raised in his mother's faith.

Shortly after a medical convention in New Orleans, after graduating medical school, Wilson accidentally broke an antique mirror and started a bar fight when another customer repeatedly played "Leave A Tender Moment Alone" by Billy Joel to the frustration of Wilson, who was going through a divorce with his first wife at the time. Out of interest, House bailed him out and hired an attorney to clear his name, thus starting both their professional and personal relationship. In the Season 1 episode "Histories", it is revealed that one of his brothers is homeless and that Wilson is unaware if he is still alive as he has not seen him in nine years. Wilson has a history of failed marriages: he is married to his third wife during Season 1 and, with the discovery of his wife's infidelity, separates from her during Season 2. After the failure of his third marriage, Wilson lives in various temporary accommodies as (including a stint at House's own apartment) until he meets Amber Volakis, who is a female substitute for House. Wilson and House's relationship has been sorely tested on many occasions.

Early Life

Wilson did well in school and was also talented athletically, he was the captain of his high school's varsity tennis team and also played the sport in college.

Higher Education

Wilson has ties to both McGill University (he is often seen wearing a sweatshirt from the university) and the College of Physicians and Surgeons at Columbia University (he has a Surgical Degree from it in his office). It is reasonable to presume he went to McGill as an undergraduate and Columbia for medical school. He also has a degree from the University of Pennsylvania where he did his specialty training in Oncology.

During this time, Wilson was trying to deal with the demands of his brother Danny Wilson, a student at Princeton University who was on medication for his schizophrenia. Danny had a habit of calling James to complain about his treatment by the professors as the medication Danny took did not totally eliminate his paranoia. However, on one occasion, James was desperately trying to study and hung up on Danny. He soon learned that Danny had left the university and didn’t take his meds, losing all contact with his family.

During his later part of medical school, he met and married his first wife, Sam Carr. It appears Sam was about a year ahead of him and that they married in medical school. The marriage was strained as Sam took an unpaid internship after medical school, leaving James to work two jobs to pay the bills as well as continuing to attend to his final year of medical school.

Chance Meeting

Shortly after graduating from medical school, Wilson decided to take some time off to attend a medical convention in New Orleans, Louisiana before starting his own internship. While he was at the convention, his wife had him served with divorce papers (the first time he knew Sam was dissatisfied with their marriage). While mulling the matter over at a bar, he got upset with a doctor who kept playing Billy Joel’s “Leave A Tender Moment Alone” on the jukebox. He got into an altercation and hurled a glass into an antique mirror. He was soon arrested and taken to jail.

However, he was soon rescued by a doctor who had also been at the convention who had been following him around, Gregory House. House became intrigued with Wilson when he saw him carrying around a parcel from a divorce attorney all weekend without opening it. He followed him to the bar and bailed him out of jail. They spent the rest of the weekend drinking together and soon became fast friends. Unfortunately, due to a misunderstanding, Wilson never attended to plead to the charges and a Louisiana warrant was issued for his arrest.

New Start

Wilson completed his internship and residency in oncology, becoming board certified. He soon found romance with a new partner, Bonnie Wilson.

Wilson enjoyed substantial career success as an oncologist. One day, House called him to let him know that Princeton-Plainsboro was looking for a new oncologist and thought it would be fun to work together. Wilson jumped at the chance, but not for the reason House thought – since Danny had disappeared in Princeton, Wilson took the opportunity to look in homeless shelters for him. He kept this secret from House for years. He only spotted Danny once during this time – while James was having dinner, he spotted him outside. However, by the time he got out of the restaurant, Danny was gone. This eventually prompted Wilson to join the Princeton-Plainsboro Teaching Hospital where he eventually became the head of the Oncology Department.

Unfortunately, Wilson’s second marriage went no better than his first. When House became disabled and his girlfriend Stacy Warner left him, Wilson started spending more time with House and less with Bonnie. Between this and Wilson’s infidelity, Bonnie finally decided to divorce him too, leaving Wilson on the hook for alimony.

However, Wilson bounced back again – he married a third time to Julie (who has never been seen in the series).

The Series

House with Wilson

Wilson is House’s constant friend and protector, often deflecting the attacks of their mutual boss Lisa Cuddy and reminding her how important House is both to the hospital and the patients despite his deficiencies.

It is during this time (after House treats a homeless patient) that Wilson finally admits to House that he has a brother that he has never talked about that he hasn’t seen in years.

The hospital is soon in turmoil when it obtains a new benefactor and chairman, Edward Vogler, who insists that all the departments be profitable. Wilson tries to advise House to get along with Vogler, but House instead stands on principle, refusing to endorse Vogler’s new expensive drug that replaces a cheaper drug that is almost as effective. Vogler tries to convince the board to revoke House’s tenure, but Wilson stands firm and refuses to allow unanimous consent. For his trouble, Wilson is voted off the board, and is forced to consider resigning his position at the hospital to avoid further damage to his career.

However, the next time House's tenure comes up, it's Cuddy who stands up for House and when Vogler’s attempt to remove her from the board fails, Cuddy manages to convince the Board to remove Vogler even despite his donation. Wilson is soon restored to his job.

We also find out that both House and Wilson love monster trucks, but when Wilson refuses an invitation on the pretence that he is giving a speech and House finds out that the speech had already been cancelled, he finds that Wilson is instead meeting Stacy. Stacy is soon back in House’s life when she seeks treatment for her husband Mark Warner.

Wilson is brought into action when Stacy returns and it appears House wants to rekindle their relationship despite her marriage. He confronts her and reminds her of the damage she did to House the last time she left. Although House and Stacy have a brief affair, House decides to end it. However, House’s pain gets worse and Wilson can’t convince him that Stacy’s departure is the reason.

Wilson also finds out that House borrowed money from him to buy a motorcycle even though House had enough money already. House admits that he borrowed the money to see how much he could borrow before Wilson refused. In retaliation, Wilson refuses to give House an excuse to get out of dinner with his parents, leading to what turns out to be House’s last face to face meeting with his father.

However, Wilson’s personal life begins to unravel as well. Fearing that his wife is angry with him for his latest infidelity, he instead finds out that she has been cheating on him. He moves out and moves in to House’s apartment. Initially, House makes out like he wants Wilson to leave as soon as possible, but instead House erases messages from potential landlords, and then tries to make Wilson’s life as difficult as possible by stealing his food and refusing to clean up.

Wilson does manage a personal accomplishment. With House out with a patient and helping Wilson to keep Cuddy playing poker instead of checking out his activities, Wilson manages to win the oncology benefit poker tournament by slow playing a pair of pocket aces and beating a pair of kings.

Wilson’s womanizing ways nearly cost him his career. He has an affair and moves in with one of his terminal cancer patients. After House figures it out and confronts him, Wilson agrees to end it and moves out on his own.

After House returns from his convalescence after being shot and having treatment that removes his leg pain, he takes on the case of a former cancer patient who is confined to a wheelchair. After performing several dangerous procedures on the patient, House comes up with the seemingly crazy idea that the patient has Addison’s disease and merely needs a shot of cortical. However, Cuddy refuses permission, only to give the patient the shot herself. As if by a miracle, the patient immediately improves, showing House was right. However, Wilson tells Cuddy she can’t tell House as if she does, he will never be controllable again.

At the same time, House’s leg pain starts to return and he asks Wilson for Vicodin. Wilson refuses, figuring that House is merely suffering aches and pains from overdoing his rehabilitation. However, House responds by stealing one of Wilson’s prescription pads and forging his signature.

The deception soon turns into a disaster. A police detective takes an interest in House after he sees House taking Vicodin in the clinic. He soon finds the faked prescriptions and asks Wilson about them. Wilson lies to the detective and says he wrote them, but it’s clear the detective doesn’t believe him.

The detective soon turns up the heat on Wilson by having his car towed and suspending Wilson’s ability to prescribe narcotics to his patients. Wilson tries to get Allison Cameron to sign off on his prescriptions, but when House calls her away to work on his case, Wilson instead gives up his oncology practice.

Wilson accompanies House on a trip to Atlantic City with a former coma patient who House has temporarily revived. When it turns out that the only way to save the patient’s son is to have him serve as a heart donor, Wilson sets up an alibi for House in a casino.

However, when House’s Vicodin is cut back, House lashes out at Robert Chase, leading Wilson to the belief that House must somehow deal with his Vicodin addiction. He starts cooperating with Tritter and tries to convince House to take a deal that will not involve jail or a risk to House’s medical license. Instead, House turns the deal down flat. In order to keep the pressure on House, Cuddy and Wilson conspire to cut House off of Vicodin completely until he agrees to the deal. Instead House steals drugs from a patient and, even though Wilson reverses himself and stops cooperating, House nearly goes to jail until Cuddy perjures herself to convince the court the stolen drugs were only a placebo.

Wilson has to intervene once again when he realizes House is plotting to get nerve tissue from a patient who is insensitive to pain in an attempt to graft the nerve cells to his own.

While House is away, Wilson takes over the team when a middle aged woman collapses in her own home. Fortunately, Chase comes through with the right diagnosis.

Wilson ends the season by angrily confronting House about the imminent departure of Eric Foreman and his subsequent decision to fire Chase, stating the decision turns House into a bastard.

Wilson puts the pressure on House to hire a new team by "kidnapping" House’s expensive guitar until he agrees to interview fellowship candidates. House finally relents when he takes a lengthy period of time to solve a case.

After the fellowship derby, House is sure that Wilson is not only dating someone, but someone House knew personally. Much to House’s dismay, it turned out to be Amber Volakis aka "Cutthroat Bitch".

Wilson's relationship with Amber Volakis came as a surprise to everyone, including Wilson and Amber themselves. Wilson realized that because Amber shared many characteristic with his best friend that they might be able to have the same type of lasting relationship. He later admitted to House that one of the reasons he liked Amber so much was because, like House, she was so much fun to be with. He also enjoyed the fact that she was much more assertive than he was. On Amber's part, she had deep seated feelings of inadequacy that drove her to demand respect and to excel to get that respect. In Wilson, she found someone who could both respect her and find her attractive and desirable at the same time. Unfortunately, the relationship ended in tragedy when Amber died as a result of kidney failure due to the pills she was taking for the flu. She was transferred to another hospital under the name "Jane Doe" but once House realized Amber was the dying patient, she was sent to PPTH where House and his team tried to save her life with little success. Amber was put on life support, eventually succumbing to the organ damage but not before she said goodbye to Wilson.

Amber's death devastated Wilson more than his three previous divorces had. Although he did not blame anyone for Amber's death, not even House, he came away from the relationship with the one lesson Amber taught him – she could take care of herself and he had to take care of himself, particularly in a relationship with someone like her. He soon came to the conclusion that he didn't want to enable House any more, but tried to hide his feelings from House in order not to hurt him by claiming he just wanted a change of scenery.

"Nobody at this hospital even liked her."
―Wilson, rejecting Cuddy's attempt to sympathize with his loss in Dying Changes Everything

After a long period of mourning, Wilson returns to the hospital to announce that he’s leaving. House tries to confront him about it, but Wilson is tired of House acting like a jerk all the time and won’t change his mind.

In an attempt to reconnect with Wilson, House hires Lucas Douglas, a private detective. Lucas soon finds out that Wilson has stayed connected with everyone at the hospital except House. House once again tries to confront Wilson about this, but Wilson blows him off again.

However, when House’s father died, Cuddy enlisted Wilson to ensure that House attended the funeral. During the trip, the two confronted the problems with their relationship and Wilson learned not only that House suspected John House was not his biological father, but that House’s suspicions were correct. He soon realized after the trip that he hadn't had any fun since Amber died until he and House were back together again. They soon reconciled and Wilson returned to his old job.

After Lawrence Kutner dies, House starts hallucinating a vision of Amber and finally turns to Wilson for help.

However, Wilson soon realizes that House is in serious trouble and Wilson accompanies him to Mayfield Psychiatric Hospital, watching from a distance as House approaches the entrance of the hospital before House eventually enters the hospital.

House quickly detoxes from Vicodin, but refuses to deal with his underlying issues. Instead of following his doctors’ treatment regimen, he tries to blackmail Dr. Nolan and tries to enlist Wilson in the attempt. However, Wilson refuses to cooperate. However, House soon agrees to treatment and is released into Wilson’s care. Wilson encourages House to start a relationship with Cuddy, but their plans are thwarted when they discover she’s dating Lucas Douglas.

House is soon reinstated and back doing diagnostic medicine. Wilson is astounded when House tries to re-form his old team, and is even more astounded when he succeeds.

When an old friend and patient of Wilson’s needs a liver transplant, Wilson finally agrees and House shows up just before the operation for support even though he thinks it’s a bad idea. House is there for the rehabilitation as well, and Wilson soon regrets his decision when the friend goes back to his new girlfriend instead of his ex-wife.

Wilson remains supportive, even moving into a larger condo in order to give House more living space. In the process, Wilson decides to make a dig at Cuddy for starting a relationship with Lucas by outbidding Cuddy for the condo she wanted. Both of them try to get together with their new neighbor Nora, but she rejects them both. When House demands that he decorate the new space himself, Wilson gets a decorator instead but gets House a thoughtful gift – a new electronic organ.

However, Wilson soon has a new relationship in mind. He reconnects with his first wife Sam on the internet and they are soon dating and, soon after that, planning to live together. Sam and House immediately earn each other’s enmity, but they agree to keep the peace for Wilson’s sake. However, at the end of the season, Wilson is asking that House move out of the condo so he can spend more time with Sam.

When House and Cuddy get together, Wilson is initially skeptical until Cuddy makes it clear how comfortable she is with House’s sexuality.

Wilson’s own relationship with Sam doesn't work out so well. Although he plans to marry her, he finds out during a review of Sam’s treatment records that she may have been overexposing terminal cancer patients to radiation in a last ditch effort to save them. Although he is supportive, Sam treats this as evidence that Wilson doesn't trust her and breaks up with him.

However, House and Cuddy break up and House reacts by driving his car through Cuddy's living room with Wilson breaking his wrist in the process.

House is eventually released from prison and returns to PPTH where he gets a cold reaction from Wilson who then finally tells House he doesn't like him. After House asks Wilson to either punch him in the face or kick him in the nuts to get over his hurt feelings, Wilson chooses the former and agrees to bring dinner around to his place. The two repair their friendship.

Things continue normally for a while up until Body and Soul where Wilson reveals that he has cancer, more specifically stage II thymoma which leaves House completely stunned.

Wilson goes for a "Hail Mary" cure, but although he survives the treatment, it doesn't work and both men realize he will be dead in no more than six months if he refuses further treatment. When Wilson tells House he has no intention of spending the rest of his life in and out of hospitals, the two men get into a fight over it. Wilson goes back and forth over his decision, but in the end, House realizes that six months is better than nothing and accepts Wilson's decision. House plans on spending his remaining time with Wilson, but one of House's pranks goes horribly wrong which results in the revocation of House's parole and his imminent return to jail.

Unwilling to let that happen, House fakes his death and he and Wilson go on a trip across America together, intending to make the most of their time together before Wilson succumbs altogether.

It's presumed that in or around September or October 2012, Wilson eventually dies from the cancer.


Wilson is by all standards one of the nicest people you could meet, as he has an unbelievable bedside manner and knows exactly how to talk to people. He also cares deeply about others, sometimes even more than he cares about himself. Patients have been known to thank him after he tells them that they're dying. He has donated blood and even organs to his patients when they cannot find matches. In the Season 6 episode, Lockdown, Dr. Remy "Thirteen" Hadley teases him, saying that he's too much of a "nice boy". He is "incapable of turning away from any responsibility" and ultimately believes that "enduring pain for someone you care about" is what life is all about. However, despite this, Wilson doesn’t seem to acknowledge or realize that House admitted to being abused by his stepfather as shown at his stepfather's funeral.

In contrast to his own personality and demeanor, Wilson generally finds friends in much darker and more dour people, such as his best friend House or girlfriend Amber. In fact, House and Wilson are so very different from each other, that the close pair of friends can be said to be "polar opposites." This social life issue causes Wilson a great deal of frustration at times. This trait makes Wilson the only person who is willing to be with House on such a close and personal level of friendship.

In addition, as House often criticizes him for, Wilson tends to be a "clingy" friend/date. This is because of how much he cares about other people, resulting in him wanting to be as involved with them as possible.

He has also demonstrated that he caves in to people's demands too easily and has trouble forming his own opinions. In the Season 3 episode, Family, House lashes out at Wilson for leaving a major decision up to the parents of a patient, and when asked what he would recommend, he simply tells the parents that it's their decision. Also, in the Season 4 episode, Living the Dream, his girlfriend, Amber Volakis, tells him that the reason that his previous marriages didn't work out was because he did whatever they wanted and he ended up resenting them. She also angrily tells him "don't you ever do that to me." This is also shown by his inability to pick his own furniture in the Season 6 episode, Black Hole, displaying how he had always placed other's needs over his own to the point he didn't even know what he himself wanted, and when asked to pick one piece of furniture to define him, he finally picks out an organ for House instead, choosing to define himself by his relationship with others (particularly House). In Season 8, Wilson even agrees to undergo debilitating chemotherapy in order to extend his lifetime for House's sake, despite not wanting the treatment for himself. Wilson constantly enables House, including drug abuse and rude behavior, but on occasion stands up to him, usually for his own good, such as refusing to help him escape the psych ward in "Broken," or refusing to take the fall for a vandalism charge in Season 8.

While Wilson is normally a calm, serious person, he does have a humorous and playful side, as well. This especially happens when he is in a good emotional state, and/or when people play pranks with him. He has also proven many times that he is more than capable of outwitting House with such examples being during the Season 2 episode, Safe where Wilson successfully sawed through House's cane so that it broke when House put his full weight on it, in Not Cancer, having learnt that House had a private eye to spy on him, Wilson deliberately hired a prostitute for a short visit and planted drug paraphernalia in his own garbage and then in the Season 8 episode, Perils of Paranoia where Wilson successfully locked House in the bathroom.

Despite his kind, and sometimes humorous nature, Wilson does occasionally get in a cranky mood. This typically happens when House pushes him to his limits, or when his issues just become difficult to handle, in general. There have also been times where Wilson has expressed some outrage or anger towards Cuddy, House himself and even some of House's team, usually for some emotional failure. This usually manifests in him "going off" on them, but is usually brief, and he typically makes up with them quickly. This happens a number of times with House. He also suffers from depression, for which he has been clinically treated. According to actor Robert Sean Leonard, he describes Wilson as "the saddest man alive... he's very lonely and a very spooky character", showing that he does suffer from a dark side.

Wilson also occasionally gets petty, such as with germs and keeping food safe, and with keeping his furniture clean. In the season 6 episode, "Open and Shut," this proves to be a challenge with his attempt to get back together with Sam. Wilson becomes annoyed when Sam puts the milk in the door shelf of the refrigerator, saying that it would be colder in the center, thus less likely to become spoiled. Wilson originally tries to ignore his annoyance with Sam not being as cautious as he is, and says nothing to her about it at first. However, House notices and uses it to try to test and sabotage the strength of Wilson's re-emerging relationship with Sam, by off-setting the dishes in the dishwasher so that there's a big bowl on the bottom shelf that blocks the water from getting to the top shelf. Thinking that Sam also did that, and not knowing it was actually House's "testing", Wilson finally asks Sam if she could be more cautious with germs, and also if she could use a coaster with her drinks on his furniture. Sam becomes surprised when he brings up and asks for all of that at once, though eventually becomes glad that, unlike before, Wilson is expressing his annoyances.

However, Wilson's high standards for detail also prove useful. In the Season 6 Episode, "Wilson," he noticed that a Cancer patient, who was in remission, did not brag about his grand kids like usual. While a seemingly minute happening, especially for a Cancer patient, Wilson thought that the patient's subtle increase of depression could be the result of new Cancer. Having done some tests as a result, there indeed was a newly formed, small Cancerous mass in the patient's lung, which didn't end up doing much harm, due to the very early catch. Wilson was then congratulated for this finding, from his attention to detail, at a board meeting. His perceptiveness also helps him accurately interpret things that House is saying, including when House lies or denies his true motives, on many occasions.

Wilson is a theatre geek who frequently references plays and musicals. Although he watches "trashy" tv with House - who prefers it as a distraction while he's thinking about a case or for pure entertainment value - Wilson loves classic cinema and puts up framed posters in his office for movies like "Vertigo", "Touch of Evil", and "Ordinary People". The plots of those movies hint at insights into Wilson's character: a man on the verge of a breakdown who can't stop trying to save a woman he ends up losing; a flawed detective who walks with a limp; and an upper-middle-class family pretending they're coping with the loss of their oldest son while the mother emotionally shuts out her younger son who is struggling with his mental health and guilt in the aftermath.

Relationship with House

Main article: Hilson

The two friends are so close that gay references have been made to the relationship between the two characters of the show. During season 2 in "The Mistake" House has made a joke about the relationship between them ("I'm gay!...Oh that's not what you meant. It would explain a lot, though: no girlfriend, always with Wilson, the obsession with sneakers..."). Verne Gay of Newsday described House's love for Wilson as "touching and genuine." Hugh Laurie said that the relationship between the characters is "not just buddydom." The two characters appeared on the cover of the October 13, 2008 issue of TV Guide. In an interview with E!, executive producer Katie Jacobs stated that there are equal chances of either Allison Cameron, Lisa Cuddy, or Wilson "ending up" with House.

The term Hilson has been coined to describe those who support a romantic relationship between the two, and in the episodes Hunting, The Tyrant and The Down Low they have been mistaken for a gay couple. This same misunderstanding has also been explored in modern interpretations of Sherlock Holmes, particularly the 2010 production “Sherlock” set in 21st century Great Britain where people often mistake Holmes and Watson for a gay couple.

One of the reasons House is so close to Wilson is that it appears it is the one relationship he has that he has no chance of ruining. There is a security to their relationship, as shown by the fact that they always come back to each other despite some harsh events (usually caused by House), as with Amber's death being inadvertently caused by House, or House crashing the car into Cuddy's home and breaking Wilson's wrist in the process. Wilson, however, is often rightfully frustrated by House’s attempts to test the strength of the relationship, such as when House deliberately borrowed increasingly large sums of money for no reason. House also occasionally manipulates, and plays games, to take advantage of and magnify Wilson's faults.

"$5,000! That’s nothing to be ashamed of."
―House’s response to Wilson expressing surprise that he was testing the friendship in monetary terms.

Wilson and House do share similar tastes. They are both big fans of monster trucks (and Wilson once used this as an advantage by claiming he didn’t like them that much to throw House off another scent). They are often attracted to the same women (even Cuddy at one point). However, at the heart of their relationship, Wilson often acts as House’s conscience, and House acts as an honest critic of Wilson’s own personality, pointing out faults such as his infidelities and his need to please everyone. In the Season 5 episode, The Social Contract, Wilson himself mentions that their relationship is abnormal, that House prefers to tell the harsh truth rather than comfort Wilson with 'collaborative lies' as many people tend to do. This peculiarity is very well a contribution to House and Wilson's long-lasting relationship, as they both know one another at their worst, and aren't afraid to call each other out on it.

One other thing that Wilson does as a regular basis is to provide House with inspiration for his cases while talking about totally unrelated matters. This happens so frequently that House has commented that his strategy is often to “talk to Wilson about something unrelated” until he reaches an answer. House is often able to solve cases by, "pulling ideas out of nowhere," from Wilson's insightfulness in their conversations.

In Not Cancer when their friendship had broken up, he went so far as to try to pay Wilson to talk about things unrelated to his current case.

In You Don't Want To Know, they made references to each other's blood type (House AB+ and Wilson O-). Their blood types mean they are two sides of a coin; House is a Universal Recipient and Wilson is a Universal Donor. This is the core of their relationship: Wilson thrives on being/feeling needed, and House is someone who will always need something. This also means Wilson can donate blood to House if necessary.


  • Wilson is played by Robert Sean Leonard who also starred in the 1989 movie, "Dead Poet's Society" which has been considered his main breakout role. The movie itself has even been referenced a few times on the show.
  • In the first seasons Wilson drives a silver Volvo S80 of the first generation. From Season 5 on he drives the new model (S80 II 4.4 V8) before he got a Ford Taurus instead in the last season. When Wilson realized he had cancer and not much time left, he bought a Corvette C6 which he crashed in Post Mortem. In the finale his Ford Taurus appears again.
  • Wilson appeared in 172 out of the 177 episodes of House, M.D., more than any other character and second only to Gregory House.
  • In Post Mortem, Wilson reveals that he cannot drive stick shift.
  • He writes with his left hand, a trait he shares with Lisa Cuddy, Eric Foreman and Jessica Adams.
  • He has been seen using his right hand for things other than writing, suggesting he may be ambidextrous.
  • He is allergic to ragweed and dandelion.
  • Wilson has been unknowingly and unwillingly drugged by House on at least four separate occasions; the first with Speed in an act of petty vindication, the second with sedatives to prevent Wilson from giving a career-ruining speech, the third with sedatives again during a dinner with House, Cuddy and her mother simply because House thought Wilson would be the worse company and the fourth in 'Holding On' when House sedates him to prove that death is nothingness.
  • He shares his initials and name structure with John Watson, and serves much the same role to House that Watson did for Sherlock Holmes.


Thanks to

  • 10-Minute Retirement: He quits his oncology practice at Princeton Plainsboro three times throughout the series: the first time he was pressured into resigning by Vogler, then once due to pressure from Detective Tritter, then again later on after Amber died. In each case, he returned to Princeton shortly thereafter.
  • All-Loving Hero: Wilson certainly fits this trope a huge percentage of the time. Giving part of your liver to your friend/patient who is dying certainly fits him in this category. In fact, he's always so ridiculously accommodating for other people, trying to help them out and take care of them, that it destroys his romantic relationships because he never wants to burden his partner with his own needs. Amber gets really pissed when he tries to take care of her.

House: (knocks on the door to Wilson's office) I know you're in there; I can hear you caring.

  • All Take and No Give: His relationship with House, most of the time, is him helping House without as much as a "thank you" in return. On the other hand, Wilson has said he values his relationship with House because he doesn't have to walk on eggshells or soften the truth with House, which is valuable for someone who has to be nice and compassionate to people all day long. Inverted when he has cancer in Season 8.
  • All Men Are Perverts: An authentic example. He cheated on at least one of his wives, even though he loved her/them. He even had a relationship with a patient. Then he met Amber.
  • Armor-Piercing Question: In "The C-Word", the hallucination of a kid who died under his treatment asks "if [he] didn't do nothing wrong, why did [he] die?". The question leaves Wilson devastated.
  • Aww, Look! They Really Do Love Each Other: Whenever he and House are particularly mean-spirited to each other, there's always a brief moment or gesture from one or the other that will make it clear how much they really care.
  • Beware the Nice Ones: Despite being a Nice Guy, he has a manipulative streak. See Manipulative Bastard below.
  • Canada, Eh?: Earned his undergraduate degree at McGill University, which is in Montreal, Quebec.
  • Chronic Hero Syndrome: Not only does he state it;

"Some doctors have the Messiah Complex - they need to save the world."

  • His love life is a victim of it. He gets into relationships with damaged women, and loses interest once they heal. On three occasions(see Serial Spouse), this happens after he marries them. Upside: at least one of the women was rather flattered by the whole thing - at least enough to chew House out for screwing with him. Downside: Wilson is stuck with House as his most significant other simply because House will never stop needing him.
  • Chick Magnet: Can't keep the ladies away, and is particularly... erm... friendly with the nursing staff.
  • The Conscience: He reminds House of stuff like the "do unto others" thingy and the "keeping your promises" thingie.
  • Consummate Liar: His best friend is House, so Wilson has become increasingly good at lying just to keep some small degree of privacy. House is so good at the Sherlock Scan that no matter how good Wilson gets at this, it never works for very long.
  • Deadpan Snarker: Usually in conjunction with House and snarking right back at him, to the point where it consists of about 90% of their dialog on the show.
  • Dead Person Conversation:
    • In "The C-Word", he talks to John Taylor, an 8-year-old who died under his care
    • In "Brave Heart": it's revealed that Wilson talks to his dead girlfriend Amber. He knows she isn't there, but it helps him cope.
  • Death by Irony: He's' an oncologist with terminal cancer...
  • Expy: Dr. Wilson's name and role echo those of Dr. Watson.
  • Extreme Doormat: Subverted. He may let House (and everyone else) roll over him most of the time, but when someone pushes him too far he stands his ground.
  • Face Death with Dignity: In Season 8, Wilson finds out that he has cancer that gives him, at absolute best, around three years to live. After the first round of chemotherapy is unsuccessful, he refuses any further treatment and decides to just enjoy the roughly 5 months he has left.
  • Failure Is the Only Option: His first two marriages ended in divorce before the series started. His 3rd marriage fails in Season 2, leaving his extremely dysfunctional relationship with House as the only one that hasn't fallen apart.
  • Finding Judas: Trope Namer and trope subject - Wilson's the one feeding information to Tritter about House.
  • Good Samaritan: He sacrifices a lot for House on a regular basis, which is often passed over. However in the episode "Wilson", we see how much attention and care he gives his patients on a daily basis, despite constantly dealing with House and the problems that follow him, which culminates when he gives his patient a part of his own liver in order to save him (and it's highly implied that if it came to it he'd probably do something similar again).
  • Guile Hero: He is the only person in the series who has successfully manipulated the title character multiple times. Not only that, but he's less of an Anti-Hero than almost the entire rest of the cast.
  • Heterosexual Life-Partners: With House. In the second and third seasons, the writers make light of the shipping.

Stacy: What are you hiding?

House: I'm gay. (Stacy glares at him) Oh! That's not what you meant. It does explain a lot though. No girlfriend, always with Wilson, obsession with sneakers...

  • Ill Boy: In the last season it's revealed that he has cancer, more specifically stage II thymoma.
  • Intoxication Ensues: From "Resignation", his infamous "I'm not on antidepressants, I'm on speeeeeeeeeeeeeeeeeeed!" (Yes, he actually holds it out.)
  • Kind Hearted Cat Lover. He takes in an old cat named Sarah in Season 7 after her owner passed away.
  • Last-Name Basis: Like everyone else, he's referred to only by his last name.
  • Living Emotional Crutch: Heavily implied in his relationship with House. While their relationship may appear to be of the All Take and No Give variety, it actually goes both ways as Wilson is not as well-adjusted as he seems, and probably needs House just as much as he is needed by him.
  • Manipulative Bastard: Wilson remains the only character who can continually lie to House, as well as the only character to one-up House.

House: You manipulative bastard, did you just invoke the name of your dead girlfriend to play me? You're my hero.

  • The McCoy: The one who feels a need to "fix" the vulnerable women he meets.
  • Mistaken for Gay: Along with House. In "The Down Low", House pretends he and Wilson are a couple as part of an insanely convoluted plan to sleep with the woman Wilson likes, and keep him from sleeping with her at the same time.
  • Nice Guy: A Nice Jewish Boy who's approachable and humanitarian-centered attitude contrasts House's cold cynicism.
  • Nice Jewish Boy: He's not necessarily nice all the time, but especially compared to House he generally seems nice. Since a lot of his patients are terminally ill, being nice is a job skill.
  • Odd Friendship: With House. They have nothing in common personality-wise, he's generally empathetic and just plain kind, and House is a sarcastic, narcissistic misanthrope. But all of Wilson's wives have been "damaged". He has a complex about rescuing people.
  • Puppy-Dog Eyes: He has big chocolate eyes. Cynical House sometimes laughs at him for it.
  • Red Oni, Blue Oni: The emotional Red Oni to House's hyper-rational and scientifically-minded Blue Oni.
  • Serial Spouse: Wilson had been divorced twice at the start of the show. He went through his third divorce in season two. At one point his second wife says "He's just so knight-in-shining armor, you know? Always there to support you, until he's not, but by then you’re hooked." He stopped being there for her because he needed to be there for House. It's implied that this is due to his Chronic Hero Syndrome. He's supportive of his girlfriends and spouses until they don't need support anymore, then he loses interest. House never stops needing him.
  • Sensitive Guy and Manly Man: An endlessly-compassionate, affection, and caring person who seems to have a bottomless well of patience; the perfect Sensitive Guy to House's Manly Man.
  • Shipper on Deck: First to House and Cameron (even as he warns her not to hurt him), then to House and Stacy (even as he warns her not to hurt him and reminds House that Stacy's married) then to House and Cuddy. Mostly, he just wants House to be happy.
  • Smarter Than You Look: It's hard for anyone to shine when standing next to House, but Wilson continually provides useful insights (that House ignores). His A Day in the Limelight episode features him diagnosing a recurrence of cancer because his patient failed to mention how his grandchildren were doing.
  • Stepford Smiler: Amber beats the "I'm always fine, dear" facade out of him.
  • Straight Man: A nice and reasonable guy to House's outrageous behavior.
  • Tragic Keepsake: The final season reveals that many of the items on the shelf behind the desk in his office are keepsakes of patients who died in spite of high chances of surviving cancer.
  • Troubled, but Cute: Good looking and charismatic, but the ups and downs of his love life, having a job that constantly puts him around terminal patients, Amber's death, and finally his own terminal cancer diagnosis really weigh heavy on a guy.
  • Two First Names: Applies to his actor too.
  • Unwitting Instigator of Doom: Decides to induce protective hypothermia in Amber rather than continue with the defibrillator, so House has more time to diagnose her. She was as good as dead when they agreed on this.
  • Vitriolic Best Buds: With House. Greg House, Dr. Jerk to the extreme, is the only person allowed to openly mock James Wilson's serial marriages and chronic neediness. They'd fall into the first category, except then you realize that Wilson's no doormat and snipes right back at House.
  • Your Days Are Numbered: Has about 5 months to live as of the series finale, due to him refusing to continue treatment.

Character page at IMDB

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