Methamphetamine hydrocloride is a cerebral stimulant that is chemically related to amphetamine. It stimulates the release of norepinephrine, a neurotransmitter, and is therefore used for short-term treatment of attention deficit disorder, narcolepsy, epilepsy and exogenous obesity.

It is contraindicated for patients with hyperthyroidism, hypertension and glaucoma in addition to those taking monoamine oxidase inhibitors (MAOIs) — deaths have been connected to the combination of these two drugs — and those who are pregnant. Common side effects are hyperactivity, insomnia, restlessness, talkativeness, palpitations and tachycardia whilst the major life-threatening side effect is circulatory collapse.

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