Oxycodone, originally synthesized during 1916 in Germany. Popularity and sales surged when a controlled release preparation was created and marketed under the trade name OxyContin. Oxycodone is a narcotic painkiller derived from the opium constituent Thebaine. It is chemically similar to codeine. Oxycodone is often sold as is, (Oxyir) or as a preparation with aspirin, (Percodan) or with acetaminophen, (Percocet). In any form, it is subject to strict regulation as a U.S. Schedule II substance.