(Trivia and Cultural References)
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|director = [[Guy Ferland]]
|director = [[Guy Ferland]]
|writer = [[Matt Witten]]
|writer = [[Matt Witten]]
|airdate = January 25, 2005
|airdate = February 08, 2005
|episode_no = 1.8
|episode_no = 1.10
|rating = 8.7
|rating = 8.7
|guest_star = [[Roxanne Hart]], [[John Patrick Amedori]], [[Shirley Knight]], [[Kurt Fuller]]
|guest_star = [[Roxanne Hart]], [[John Patrick Amedori]], [[Shirley Knight]], [[Kurt Fuller]]

Revision as of 01:34, September 20, 2013

Season One Episodes:

  1. Pilot
  2. Paternity
  3. Occam's Razor
  4. Maternity
  5. Damned If You Do
  6. The Socratic Method
  7. Fidelity
  8. Poison
  9. DNR
  10. Histories
  11. Detox
  12. Sports Medicine
  13. Cursed
  14. Control
  15. Mob Rules
  16. Heavy
  17. Role Model
  18. Babies & Bathwater
  19. Kids
  20. Love Hurts
  21. Three Stories
  22. Honeymoon


This article is about the episode. For information about poisons, see Toxin
Margo Davis: "What makes you think you're right this time"
House: "Same reason as last time."

Poison is a 1st season episode of House which first aired on January 25, 2005. House tries to blow off a case of a sick teenager, but when the obvious explanations are ruled out he gets interested. He soon figures out the correct diagnosis, but when the patient takes a turn for the worse, pinning down the exact cause of the patient’s illness soon becomes vital. Just when House figures he’s got it right, another patient shows up who seems to have no connection to the original patient. When House thinks he’s found the right answer, he finds that the patient’s mother has lost all faith in him and won’t allow treatment.


A high school student gets nausea, abdominal pain, and dizziness and then collapses during a calculus exam.

The patient is taken to Princeton-Plainsboro. Eric Foreman convinces Gregory House to take the case by saying he has ruled out all the obvious diagnoses. The team starts a differential based on the patient's negative tox screen. Robert Chase talks to the patient, but his mother is there interfering with the questioning - she denies her son takes drugs. She admits that she has tested his hair for drugs. She denies he has ever had a similar problem. At that moment, the patient has a seizure.

Allison Cameron and Foreman search the patient's home for drugs. Foreman thinks House is doing it because House thinks everyone is an addict. However, they do find spoiled tomato sauce.

They report back to House, who brushes off the diagnosis of botulism because of the seizure. House thinks it is organophosphate poisoning.

They treat the patient for the poisoning, but he doesn't improve. The patient's mother is getting more and more frustrated. Foreman suggests a targeted approach and House agrees. Foreman also suggests trying to find the source of the poison. Chase performs a procedure to directly stimulate the patient's heart rate.

Cameron goes back to the patient's home looking for pesticides. She finds an empty can of disulfoton, an insecticide, but the mother says it was empty and contained orange peel oil, but Chase insists they are right. The mother refuses treatment.

House thinks they should get a court order, but Lisa Cuddy realizes they will never get it because the only symptom is that the mother disagrees with House. She suggests House get a waiver from the mother saying she's refusing treatment. House confronts the mother with the waiver and asks her to sign it. Instead, the mother agrees to treatment. However, before they can start, a second patient with the same symptoms appears in the emergency room. The new patient lives 10 miles from the first patient and they don't know each other.

The second patient's mother and father say there are no pesticides in their home. The first patient's mother wants Chase off the case because he said he used drugs in high school. The team starts working on commonalities between the two patients. He finds out that they take the same bus to school.

Cameron and Chase go to the bus to search it. Meanwhile, the first patient's mother has lost confidence in House for trying to give her son the wrong medicine. When Foreman defends him, she turns on him too. The bus driver says that he did see a pesticide spraying truck on the route.

The first patient's mother gets in touch with the CDC and won't let the team treat her son until they get back to her. Cameron tries to talk to the mother, but she won't listen. Cameron confronts her, and the mother agrees to treatment. They start treating both patients, but neither improves.

Instead, they both start having seizures. While Matt starts seizing, Margo calls for help. Seconds later, Ling begins seizing too. Chase and Cameron try to stabilize Matt while Foreman looks after Ling. They manage to stabilize both patients.

The patients's hearts, lungs and livers are all in distress. They figure due to the heart problems, they absorbed the poisons through the skin before they got on the bus. They concentrate on what they did first thing in the morning. They go to both patient's houses for anything they could both have used. Cameron and Foreman find they use the same laundry detergent. However, the second patient's parents deny that their child ever did the laundry, and that the clothes he was wearing were brand new. House goes to look at the first patient's clothes - they look old, but they are in fact new (the label isn't faded). House orders them tested. They find phosmet. The second patient's parents agree to treatment, but the mother of the first patient won't.

House goes to see the mother, and waits until she agrees. She still wants to wait for the CDC, but House says there is no time. She gets a call from the CDC, and they say they can't give her an opinion until the following week. She agrees to the treatment. However, the phone call was placed by Chase, who was putting on a Southern accent.

Both patients improve and regain consciousness. The mother learns about the deception, but doesn't mind - she tells her son they're the arrogant jerks who saved his life. They trace the poison to stolen clothes that were stored in a truck that held the pesticide.

Clinic Patient

A man brings in his elderly mother, Georgia, saying that she's been in too good a mood recently. She admits she's been having fantasies about younger men, like Ashton Kutcher. She then starts flirting with House. He orders tests and tells the son that because of the sudden personality change, it is probably serious and not just the result of advancing age.

Georgia starts writing love poetry about House and Wilson finds it; he proceeds to read it aloud for House and other staff to hear. Her test results show she has syphilis despite not having had sex for over a decade. She admits she was diagnosed back in 1939 when she was a teenager before it was treated with penicillin. Her son is shocked. It was dormant and has recently started attacking her brain, causing her personality change. House prescribes penicillin.

She later returns to the hospital to see House. She tells him she doesn't want to be treated because the brain damage makes her feel so good. He tells her that the damage to her cerebral cortex is permanent - she is "doomed to feel good for the rest of (her) life." She promises to come see him for a checkup once she's no longer contagious.

Zebra Factor 5/10

Organophosphate poisoning is one of the most common causes of accidental poisoning. In fact, House came to the right diagnosis almost immediately. However, it is somewhat rarer in urban dwellers as pesticides are usually used in quantity in rural areas.

Major Events

  • House meets an eighty-two year old woman named Georgia in the clinic who ends up developing a huge crush on him but the underlying cause is eventually revealed to be syphilis.
  • House continues to pick on Foreman.
  • House's team starts telling Foreman, that he and House are very alike. Foreman denies it, but after Mrs. Davis tells her son, that Foreman and House are "arrogant jerks", they both look at their shoes and see that they are the same.

Trivia and Cultural References

  • The Advanced Placement Calculus Exams are tests that allow American high school students to obtain college credit for basic calculus courses so that they may move on to more advanced courses once they do reach college.
  • Ashton Kutcher is an American actor who first came to prominence in the role of Michael Kelso in That 70’s Show. He has appeared in a number of movies and is the host of several reality shows, the most prominent of which was Punk’d. He was married to actress Demi Moore.
  • When the patient's mother insists on waiting for a second opinion from the CDC, Wilson says, "Godot would be faster," referencing the play Waiting for Godot by Samuel Beckett in which two people spend a long time waiting for someone named Godot who never arrives. Wilson would later make another reference to this play in the episode Finding Judas.
  • Chase faked a southern accent when he impersonated a CDC official. The Centers for Disease Control and Prevention is located near Atlanta, Georgia, sometimes called "the capital of the New South".
  • Georgia's case is based on a real life case described by Oliver Sacks. A 90 year old woman named Natasha K. developed an increased sex drive and did not want to be treated for the advanced syphillis that caused it. Like House, Sacks assured her the treatment wouldn't affect her sex drive. The case is recounted in The Man Who Mistook His Wife for a Hat and Other Clinical Tales.[1]


Matt's Mother to Cameron:

"You're the one with the sympathetic honesty. And looks."

House after Matt seizes:

"Looks like Matt's mom won't be nominating us for the doctor of the year award."


"I'm extremely disappointed. I send you out for exciting new designer drugs, you come back with tomato sauce."
'House: "I assume 'minimal at best' is your stiff upper lip British way of saying 'no chance in hell."
Chase: "Actually, I'm Australian."
House: "You put the Queen on your money, you're British."
— Poison
Matt's Mother: "Who are you?"
House: "I'm the doctor who's trying to save your son. You're the mom who's letting him die. Clarification. It's a beautiful thing."
— Poison

House: "Mr. Adams, would you step outside for a moment?"
Adams: "Why?"
House: "Because you irritate me."
— Poison


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